Endocrine Abstracts

The AR pathway accumulates myriad genomic and transcriptomic alterations during progression of prostate cancer to a lethal castration-resistant phenotype. The best characterized alterations are point mutations or amplification of the AR gene. More recently, our group had identified structural rearrangements in the AR gene as a novel class of alterations that occur frequently in castration-resistant prostate cancer (CRPC) tissues. AR gene rearrangements are associated with outl...

The androgen receptor (AR) functions as a master transcriptional regulator of prostate tissue homeostasis. This master transcriptional regulator function is maintained in prostate cancer. Therefore, prostate cancer is an androgen-dependent disease and suppression of AR transcriptional activity with androgen deprivation therapy (ADT) is an effective systemic therapy. However, development of therapy resistance and transition to castration resistant prostate cancer (CRPC) represe...